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KMID : 0941819910010010009
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Korean Journal of Clinical Pharmacy
1991 Volume.1 No. 1 p.9 ~ p.14
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Bioavailability Studies on Suspension of Inclusion Complexes of Piroxicam with Cyclodextrins
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박선희
이창훈/최영옥/박기배/김종갑
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Abstract
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Inclusion complexes of piroxicam with alpha,;beta;and;gamma- cyclodextrins were prepared and suspended to enhance the bioavailability of piroxicam. A quantitative analysis was employed HPLC for the determination of piroxicam in the rabbit serum after a single oral dose in suspension of piroxicam and each of inclusion complexes of piroxicam with alpha,;beta;and;gamma- cyclodextrins, respectively. The bioavailability and serum level of piroxicam exhibited the highest in piroxicam clathrated beta-cyclodextrin than both piroxicam and the other complexes administered. and the total area under the curve of serum concentration versus time for their inclusion complexes were larger than that of piroxicam.
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